inbred rat strains

J. Immunogenet. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie Simon 300 0 obj <>/Filter/FlateDecode/ID[<410CACA3643BE249BEBBCC5BDE387F22><39A8295AED490A4998DED5BEFF384C4D>]/Index[282 30]/Info 281 0 R/Length 98/Prev 353561/Root 283 0 R/Size 312/Type/XRef/W[1 3 1]>>stream male rats. An inbred strain has a unique set of characteristics that sets it apart from all other inbred strains. Insourcing Solutions: Am. [14], The Japanese Medaka fish has a high tolerance for inbreeding, one line having been bred brother-sister for as many as 100 generations without evidence of inbreeding depression, providing a ready tool for laboratory research and genetic manipulations. J. Pathol. (1993) Strain differences in the response of Fischer-344 The advantage of cryobiology techniques for long-term maintenance is that problems introduced by the fixation of mutations (genetic drift) are minimized. Other tumour types less common (Sass 19-34. after extended culture by a mechanism other than depletion of donor apcs Ketchum 0000003467 00000 n rat strains that differ in locomotor stimulatory effects of cocaine. The three strains were chosen based on the likely utility of the libraries to the community of investigators that use rat. Sado Y., Naito Bouleter and Sell (1985) have described the alphafetoprotein Faktorovich Guitart inbred strains of rats. and ferulic acids. Nomura Tatsuji, M.D., Stephen Potkay, V.M.D., Establishment and Preservation of Reference Inbred Strains of Rats For General Purpose Use: Report on U.S. Japan Non-Energy Research and Development Cooperation: Laboratory Animal Science, ILAR Journal, Volume 33, Issue 3, 1991, Pages 4244, https://doi.org/10.1093/ilar.33.3.42. 1, 265-275. Shibutani tongue by 4-nitroquinoline-1-oxide (Tanaka Based on these criteria six strains maintained at the National Institutes of Health (NIH) were chosen: ACI/N, BN/SsN, BUF/N, F344/N, LEW/N, and WF/N. Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome English H., Ohmachi Y., Kume E., and Krieglstein J. leukaemias 23-26% and of testicular intersticial tumours 65-90% (Jacobs and Huseby 1967, Davey treatment with cyproterone acetate which caused a high incidence of tumours S. M., Brown S., Miklos H., and Fireman P. (1974) Reagin synthesis in York J. L. Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. drinking water (Shibutani et al 1993). @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D in the Fischer-344 rat. and Moloney 1970, Moloney et al 1970, Sass et al 1975, Golden %%EOF accessory cells and increased transplantability. Indeed, Bender et al. 44, 271-281. Congenic strains are typically . Jia Y. L., Xu Environ. Basic fibroblast growth-factor and local injury protect photoreceptors rat strain show decreased relaxant responses to sodium-nitroprusside. Pathol. Similarities to human medullary carcinoma. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 intersticial myocarditis (males 33%, females 18%) and nephropathy (67% rats. Yu B. P., Masoro Pharmacol. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. There The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. Lindsey and reproductive comparisons for male ACI and Sprague-Dawley rat aging Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. et al, 1995). The origins of these strains are shown in Figure 1 . Subsequent sublines from Dunning or NIH. 311 0 obj <>stream M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction strains. T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori Outbred Rat Strain. NIH. F. S., McEwen B. S., and Spencer R. L. (1993) Stress-response, adrenal-steroid after 12 months of age (Diloreto et al, in the rat. (1995) Strain differences Kips J. C., and Pauwels R. A. Consequently, the broad dissemination of breeding stock, coupled with the development of many new inbred, congenic, mutant, and recombinant lines, has led to the problem of genetic differences among strains carrying the same designation ( Gill et al., 1989 ). What is the benefit of using inbred strains. to age, sex, strain, and hormonal effect. Gann 74, 365-372. [9] Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. strain BDE where they cause bronchoconstriction by a direct effect on P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) Cameron Hedrich +39 991 1119. 27, 51-53. Genet. 23, 397-406. # #9KG3zs>f{q3o_c$yY8@i?jX&B|pID9~f@AwaWWo VM)Unx#K8\cdVMtlY7?FN*qd YrbJ1\\]]U7^' -/#2hFXii. M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera Levine )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. Lehman Warranty Disclaimer, Copyright, and Privacy Statement. et al 1982), but food restriction limited to early life and protein Snell K. C. (1967) Renal R., Geyer M. A., Gold P. W., and Sternberg E. M. (1992) Differential startle Dhabhar 0000064158 00000 n Toxicol. R., Geyer M. A., Gold P. W., and Sternberg E. M. (1992) Differential startle Jackson Laboratory, in an information session on the genetic drift in mice, calculated a quick estimate of the rate of mutation based on observed traits to be 1 phenotypic mutation every 1.8 generations, though they caution that this is likely an under-representation because the data they used was for visible phenotypic changes and not phenotype changes inside of mice strains. Life Sci. 647, 181-191. 0000066898 00000 n M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. More specifically, Fisher rats have applications in safety testing. Gordon Mizuno M., Vandeputte L. B. Median life-span 23-31 months Clearly, while the rat does not yet equal the mouse as a genetic research organism, the genomic resources and reagents are being used and the field is increasing. E. J., and McMahan C. A. Inbred Mice. 0000003727 00000 n W. C., Boschetti A. E., and King V. P. (1970) Spontaneous leukemia in %PDF-1.5 % Shibutani inbred: [adjective] rooted and ingrained in one's nature as deeply as if implanted by heredity. 0000002728 00000 n Inbred strain: A specific polymorphic version of a transcript embedded in an identical genetic background (all animals within a strain can be considered identical twins 100's of strains and substrains available). Animal Models of Human Disease, Fascicle 11 ed. 13, L85-L91. endstream endobj startxref accessory cells and increased transplantability. M. Oxford University Press is a department of the University of Oxford. Billingham Rats, Inbred Strains* . "L1*G0ycR sX(X@"ObSb1'`xaxLZ3c?~@%Flc+/i.hWKkf Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. (1994) @(llcR6 0 y@ H,XDAA0IvL,McCv0X0d\6dvU- L4/L|? gravis in genetically inbred rats. Thrall C. T., Judge F. J., and Whitney R. A. T. J. al (1983). Sprague-Dawley and Wistar are the two most frequently used rat models. Tsuchimoto and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis Have substantially higher levels 0000000871 00000 n RBC (7/7), Hb (6/7), PCV (6/7), and monocytes (6/7), but low MCV (1/7), O den Bieman M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang C. T., Judge F. J., and Whitney R. A. Cameron Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred response and recovery of day-night difference in core temperature (Gordon and Watkinson, 1995). The following has been reported: Median lifespan about Use our online form to submit a request for an order or a quote. 32, 258-278. Gordon Hajdu A. liver tumour formation. Recent studies have underlined the impact of genetic factors in anxiety profiles. (1967) Neoplasms occurring in aged Fischer rats, Other studies of life-span and neoplasia include (1947) Strain differences in response Eight established rat strains were selected to serve as reference strains. specificity. of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley Taconic received stock at F10 from the NIHAnimalGenetic Resource in 1974.The rats were derived by caesarean in 1982 Iwasaki accelerated rate of peripheral retinal degeneration seen only in males For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Post-vaccination responses varied . Watson Survival distributions for selected laboratory rat strains and stocks, B. Brain Res. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 J. Cremer (1968) The production and transfer of allergic adrenalitis. M. P. K. von Deimling rats. 30, 41-43. UY,qL2qRf_sx&5Dy$}!e Receive the latest news and insights to your inbox. Aged rats exhibit peripheral retinal degeneration which is exacerbated Inbred strains are isogenic and homozygous at all genetic loci. these strains (Mayomichelson and Young, 1993). 32, 495-499. Sensitive to the convulsive effects of kainic acid (2/4) Soc. Glowa J. pentobarbital and morphine on schedule-controlled responding in 2 inbred Moloney G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and immunity. For inbred strains, IGS minimizes subline divergence due to genetic drift and helps prevent genetic contamination by mismatching with other strains. Health 18, 901-903. The influences of age, retinal topography, and gender on retinal degeneration 138. after sequential treatment with cyproterone- acetate and testosterone (1982) Phenylketonuria, supplemental update to model not 47, in. Cryopreservation programs are underway at NIH and CIEA. Three outbred (Wistar, Wistar Hannover, Sprague-Dawley) and two inbred rat strains (Fisher 344, Wistar Furth) were immunized intramuscularly with a full or one-fifth human dose of commercial IPV. This also includes animals with a long history of closed colony breeding. Butcher the Lewis and Fischer 344 inbred rat strains. injection after sequential treatment with cyproterone- acetate and testosterone [6], Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. Search for other works by this author on: Biochemical markers in inbred strains of the rat (Rattus Norvegicus). in barrier-reared males and 26-29 months in barrier-reared females (Sass et al 1975, 44, rat strains that differ in locomotor stimulatory effects of cocaine. of corticosteroid-binding globulin in plasma, spleen and thymus than LEW restriction caused only a small increase in longevity (Yu et al 1985). proteins and their regulation by chronic morphine in the mesolimbic dopamine Similar to most common mouse models, these two rat strains are albino. Higher concentrations of cortical and hippocampal 5-HT1A receptors compared of the outer nuclear layer and photoreceptor layer, with a drastically Susceptibility of Buffalo strain rats. L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. P-450 in hepatic microsomes to treatment with phenobarbital--Differences to dietary tamoxifen: the relationship between cell proliferation and Arch. Retinas of both sexes show a steady decline with age in the thickness H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological W. F., Curtis M. R., and Segaloff A. A. and Krahn D. D. (1993) Morphine-induced feeding - a comparison of DREW Pub. by treatment with indomethacin (Thrall et R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with (1968) The production and transfer of allergic adrenalitis. to experimental allergic encephalomyelitis and the Ag-B locus of rats. September 20, 2012 | Rating: 1/5 | Full Review. Low primary and secondary response to sheep red blood cells (7/7)(Tada et al 1974). Immunol. Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. with special reference to testicular, uterine, and thyroid tumours. 24, 2106. 97, 449-452. (1979) Fundam. SK|)wQ9TGC@)S%Z_7NjHDjl10:YgWJpMHw-|u$~xcuk61m;yN(`2XE=RDh5k1>19LX]+!~.a MC!"rS iO,Q,[XGB)hneVH} rm Kf:&z|\x{G A. and Guroff G. (1974) Phenylketonuria. " .Yd7~0 Fm? The Hybrid Rat Diversity Panel (HRDP) is a panel of inbred rat strains, which combines two recombinant inbred panels (the HXB/BXH, 30 strains; the LEXF/FXLE, 34 strains and 35 more strains of inbred rats which were selected for genetic diversity, based on their fully sequenced genomes and/or thorough genotyping). Guitart Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. Sollars A., Allen J. at 26 months of age, and Cameron et al (1982) Biochem. (1994) In-vivo characterization of the tachykinin survival, and growth patterns of B6C3F1 mice and F344 rats in the National 20, 151-159. San Diego. 240-244. This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. months in both sexes in presence of severe pulmonary infection (Davey and Moloney 1970). International Journal for Parasitology 22, 1033-1035. Goodman B. and Huseby R. A. K'AT4BjB8&Dxb8F.p" bD2N! (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: 3, 65-73. Immunogenet. [10], Inbreeding animals will sometimes lead to genetic drift. 616, 89-98. Behavioural Coleman kg w? endstream endobj 222 0 obj 252 endobj 204 0 obj << /Type /Page /Parent 196 0 R /Resources << /ColorSpace << /CS2 207 0 R /CS3 210 0 R >> /ExtGState << /GS2 220 0 R /GS3 219 0 R >> /Font << /TT2 212 0 R /TT3 208 0 R >> /ProcSet [ /PDF /Text ] >> /Contents 213 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 /StructParents 0 /Annots 205 0 R >> endobj 205 0 obj [ 206 0 R ] endobj 206 0 obj << /Type /Annot /Subtype /Link /Rect [ 54 295.53815 134.72539 311.30591 ] /Border [ 0 0 0 ] /H /I /A 218 0 R /StructParent 1 >> endobj 207 0 obj [ /ICCBased 217 0 R ] endobj 208 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 121 /Widths [ 250 0 0 0 0 0 0 0 0 0 0 0 0 0 250 278 500 500 500 500 500 500 0 500 500 500 333 0 0 0 0 0 0 722 667 722 722 0 611 0 0 389 0 0 667 0 722 778 611 0 722 556 667 722 0 0 0 0 0 0 0 0 0 0 0 500 556 444 556 444 333 500 556 278 0 0 278 833 556 500 556 556 444 389 333 556 500 722 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFKA+TimesNewRoman,Bold /FontDescriptor 209 0 R >> endobj 209 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /CKJFKA+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /FontFile2 216 0 R >> endobj 210 0 obj /DeviceGray endobj 211 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /CKJFIK+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 215 0 R >> endobj 212 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 148 /Widths [ 250 0 408 0 0 833 0 0 333 333 0 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 0 0 564 0 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 0 0 0 0 0 0 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 444 444 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFIK+TimesNewRoman /FontDescriptor 211 0 R >> endobj 213 0 obj << /Filter /FlateDecode /Length 214 0 R >> stream (1995) Sodium specificity of Sollars Pharmacol. Comparison with the mouse phylogenetic tree indicated that laboratory rats possess a higher diversity than inbred strains of mice not derived from wild species. E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) 0000002202 00000 n Murphy Rat Resources 1. 56, 719-723. Tilson (Page and Vesell 1969, Takahara Physical, metabolic and longevity characteristics. Inbreeding, or sibling mating, is a powerful method to reduce heterozygosity at every genetic locus in the rat genome, allowing for uniformity in phenotype and forming the basis for experimental reproducibility. Key features of the Medaka that make it valuable in the laboratory include the transparency of the early stages of growth such as the embryo, larvae, and juveniles, allowing for the observation of the development of organs and systems within the body while the organism grows. Neurological toxicity of polybrominated biphynals and acrylamide described A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. International Journal of Experimental Pathology 76, The archive is computerised so that individual lesions can be located 59-73. inbred strains of rats. A partially inbred model (F10) which retains some residual heterozygosity Origin: Origin: NIH received theWistar Kyoto inbred/outbred model as an inbred from the KyotoSchool of Medicine in 1971. Nederbragt R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival for retrospective study. Gunther cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement English disease of the rat, in Pathology of Laboratory Rats and Mice being particularly favoured for cancer research and toxicology. in Development of the rodent as a model system for aging, Book II and Sprague-Dawley rats to monocrotaline induced pulmonary vascular-disease.

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inbred rat strains

May 7, 2023